Publications

Nguyen AD, Nguyen TA, Martens LH, Mitic LL, and Farese RV, Jr. Progranulin: at the interface of neurodegenerative and metabolic diseases. Trends Endocrinol. Metab. 2013; 24(12), 597-606.  PDF  PMC Article

Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, and Farese RV, Jr. Secreted progranulin is a homodimer and is not a component of high-density lipoproteins (HDL). J. Biol. Chem. 2013; 288(12), 8627-8635.  PDF  PMC Article

Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Xu X, Karydas AM, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, and Farese RV, Jr. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc. Natl. Acad. Sci. U.S.A. 2018; 115(12), E2849-E2858.  PDF  PMC Article

Nguyen AD*, Nguyen TA*, Singh RK*, Eberlé D*, Zhang J, Abate JP, Robles A, Koliwad SK, Huang EJ, Maxfield FR, Walther TC, and Farese RV, Jr. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 2018; 277, 145-154.  PDF

Nguyen AD, Malmstrom TK, Niehoff ML, Aziz A, Miller DK, and Morley JE. Serum progranulin levels are associated with frailty in middle-aged individuals. PLoS One. 2020; 15(9), e0238877.  PDF

He L, de Souto Barreto P, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, and Vellas B; for the MAPT/DSA Group. Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults. Alz. Res. Ther. 2020; 12(1), 128. PDF PMC Article

Raffin J, de Souto Barreto P Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Rolland Y, and Vellas B; for the MAPT/DSA Group. Associations between physical activity, blood-based biomarkers of neurodegeneration, and cognition in healthy older adults: The MAPT study. J. Gerontol. A. Biol. Sci. Med. Sci. 2021; 76(8), 1382-1390. PDF

He L, de Souto Barreto P, Giudici KV, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, and Vellas B; for the MAPT/DSA Group. Cross-sectional and longitudinal associations between plasma neurodegenerative biomarkers and physical performance among community-dwelling older adults. J. Gerontol. A Biol. Sci. Med. Sci. 2021; 76(10), 1874-1881. PDF

He L, de Souto Barreto P, Aggarwal G, Nguyen AD, Morley JE, and Vellas B; for the MAPT/DSA Group. Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults. Sci Rep. 2021; 11(1), 13394. PDF PMC Article

Banerjee S*, Ghoshal S*, Girardet C*, DeMars KM, Yang C, Niehoff ML, Nguyen AD, Jayanth P, Mersman BA, Xu F, Banks WA, Hansen KM, Zhang J, Candelario-Jalil E, Farr SA, and Butler AA. Adropin expression correlates with age-related neuropathologies in the human brain and improves neuroinflammation and cognitive function in aging mice. NPJ Aging Mech. Dis. 2021; 7(1), 23. PDF

Ayala YM and Nguyen AD. RNA-based therapies for neurodegenerative diseases. Mo. Med. 2021; 118(4), 340-345. PDF PMC Article

Nguyen AD, Malmstrom TK, Aggarwal G, Miller DK, Vellas B, and Morley JE. Serum neurofilament light levels are predictive of all-cause mortality in late middle-aged individuals. eBioMedicine. 2022; 82, 104146. PDF PMC Article

Dedert C, Vandana M, Aggarwal G, Nguyen AD, and Xu F. Progranulin preserves autophagy flux and mitochondrial function in rat cortical neurons under high glucose stress. Front. Cell. Neurosci. 2022; 16, 874258. PDF PMC Article

Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, and Farese RV, Jr. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat. Commun. 2022; 13(1), 5924. PDF

Aggarwal G, Morley JE, Vellas B, Nguyen AD, and Butler AA; for the MAPT/DSA Group. Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults. GeroScience. 2023; 46(1), 897-911. PDF

Aggarwal G, Malmstrom TK, Morley JE, Miller DK, Nguyen AD, and Butler AA. Low circulating adropin levels in late-middle aged African Americans with poor cognitive performance. NPJ Aging. 2023; 9(1), 24. PDF PMC Article

Smith DM, Niehoff ML, Ling K, Jafar-Nejad P, Rigo F, Farr SA, Wilkinson MF, and Nguyen AD. Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn^R493X mouse model of frontotemporal dementia. PLoS One. 2023; 18(3), e0282822. PDF PMC Article

Aggarwal G, Banerjee S, Jones SA, Benchaar Y, Bélanger J, Sévigny M,Smith DM, Niehoff ML, Pavlack M, de Vera IMS, Petkau TL, Leavitt BR, Ling K, Jafar-Nejad P, Rigo F,Morley JE, Farr SA, Dutchak PA, Sephton CF, and Nguyen AD. Antisense oligonucleotides targeting themiR-29b binding site in the GRN mRNA increase progranulin translation, J. Biol. Chem. 2023; 299(12), 105475. PDF JBC Article

Smith DM, Aggarwal G, Banerjee S, Niehoff ML, Jones SA, Farr SA, and Nguyen AD. Biochemical, biomarker, and behavioral characterization of the Grn^R493X mouse model of frontotemporal dementia. Mol. Neurobiol. 2024; 61(11), 9708-9722. PDF

Stevens JR, Girardet C, Zhou M, Gamie F, Aggarwal G, McMillan RP, Hulver MW, Martinez LO, van der Brug M, Vellas B, Nguyen AD, Seldin MM, and Butler AA; for the MAPT/IHU HealthAge Open Science Group. Adropin expression reflects circadian, lipoprotein, and mitochondrial processes in human tissues. Mol. Metab. 2025; 99, 102196. PDF

For a complete list of Andy’s publications, click here.